ADC Antikörper

Produktnummer ABIN5647667

Produktdetails anti-ADC Antikörper

Target: ADC (Arginine Decarboxylase (ADC))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids C111-Q301 from the human protein were used as the immunogen for the AZIN2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the AZIN2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu ADC

Target: ADC (Arginine Decarboxylase (ADC))

Andere Bezeichnung: AZIN2 / Antizyme inhibitor 2 (ADC Produkte)

Synonyme: MGC134604 antikoerper, azi2 antikoerper, odc2 antikoerper, odc-p antikoerper, odc1l antikoerper, xodc2 antikoerper, ADC antikoerper, AZI2 antikoerper, ODC-p antikoerper, ODC1L antikoerper, 4933429I20Rik antikoerper, AZIN2 antikoerper, Azi2 antikoerper, B930082O19 antikoerper, Odcp antikoerper, RGD1564776 antikoerper, odc1-b antikoerper, arginine decarboxylase antikoerper, antizyme inhibitor 2 antikoerper, biosynthetic arginine decarboxylase SpeA antikoerper, biosynthetic arginine decarboxylase SpeA (ADC) antikoerper, pyruvoyl-dependent arginine decarboxylase antikoerper, antizyme inhibitor 2 S homeolog antikoerper, AZIN2 antikoerper, azin2 antikoerper, adc antikoerper, speA antikoerper, Mrub_2839 antikoerper, MMAH_RS09440 antikoerper, Arnit_1968 antikoerper, Mesil_3114 antikoerper, Trad_0080 antikoerper, Spirs_3255 antikoerper, LOC100233080 antikoerper, Azin2 antikoerper, azin2.S antikoerper

Hintergrund: Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like AZIN1, AZIN2 interacts with all three antizymes and stimulates ODC activity and polyamine uptake. However, unlike AZIN1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, AZIN2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that AZIN2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.

UniProt: Q96A70