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Rekombinanter CD40L (Ruplizumab Biosimilar) Antikörper

Reaktivität: Human FACS, WB, BR Wirt: Human Monoclonal hu5c8 unconjugated Recombinant Antibody
Produktnummer ABIN5668046
  • Target Alle CD40L (Ruplizumab Biosimilar) Produkte
    CD40L (Ruplizumab Biosimilar)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 3
    • 1
    Human
    Wirt
    • 1
    • 1
    • 1
    Human
    Klonalität
    • 3
    Monoklonal
    Konjugat
    • 3
    Dieser CD40L (Ruplizumab Biosimilar) Antikörper ist unkonjugiert
    Applikation
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Blocking Reagent (BR)
    Spezifität
    The antibody binds to CD40L with an IC50 of 0.845 μg/mL.
    Produktmerkmale

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Aufreinigung
    Purified antibody.
    Reinheit
    > 98 % as determined by SDS-PAGE
    Endotoxin-Niveau
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    Human CD40L
    Klon
    Hu5c8
    Isotyp
    IgG1 kappa
  • Applikationshinweise
    The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531? ±?155 hours.
    Kommentare

    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    CD40L (Ruplizumab Biosimilar)
    Abstract
    CD40L (Ruplizumab Biosimilar) Produkte
    Synonyme
    CD154 antikoerper, CD40L antikoerper, HIGM1 antikoerper, IGM antikoerper, IMD3 antikoerper, T-BAM antikoerper, TNFSF5 antikoerper, TRAP antikoerper, gp39 antikoerper, hCD40L antikoerper, CD40 ligand antikoerper, CD40LG antikoerper
    Substanzklasse
    Biosimilar
    Hintergrund
    CD154, CD40 ligand, tumour necrosis factor ligand superfamily member 5, TNFSF5, tumour necrosis factor related activation protein, TRAP
    UniProt
    P29965
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