Rekombinanter CD40L (Ruplizumab Biosimilar) Antikörper
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- Target Alle CD40L (Ruplizumab Biosimilar) Produkte
- CD40L (Ruplizumab Biosimilar)
- Antikörpertyp
- Recombinant Antibody
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser CD40L (Ruplizumab Biosimilar) Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Western Blotting (WB), Blocking Reagent (BR)
- Spezifität
- The antibody binds to CD40L with an IC50 of 0.845 μg/mL.
- Produktmerkmale
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OriginalSpeciesName: Human
OriginalFormat: IgG1
- Aufreinigung
- Purified antibody.
- Reinheit
- > 98 % as determined by SDS-PAGE
- Endotoxin-Niveau
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogen
- Human CD40L
- Klon
- Hu5c8
- Isotyp
- IgG kappa
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anti-CD40L (Ruplizumab Biosimilar) antibody
Reaktivität: Human FACS, WB, BR Wirt: Human Monoclonal hu5c8 unconjugated Recombinant Antibody
anti-CD40L (Ruplizumab Biosimilar) antibodyResearch Grade Reaktivität: Human FACS, ELISA Wirt: Humanized Monoclonal unconjugated Recombinant Antibody
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- Applikationshinweise
- The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531? ±?155 hours.
- Kommentare
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % Proclin 300.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- CD40L (Ruplizumab Biosimilar)
- Abstract
- CD40L (Ruplizumab Biosimilar) Produkte
- Synonyme
- CD154 antikoerper, CD40L antikoerper, HIGM1 antikoerper, IGM antikoerper, IMD3 antikoerper, T-BAM antikoerper, TNFSF5 antikoerper, TRAP antikoerper, gp39 antikoerper, hCD40L antikoerper, CD40 ligand antikoerper, CD40LG antikoerper
- Substanzklasse
- Biosimilar
- Hintergrund
- CD154, CD40 ligand, tumour necrosis factor ligand superfamily member 5, TNFSF5, tumour necrosis factor related activation protein, TRAP
- UniProt
- P29965
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