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Rekombinanter EGFR (Matuzumab Biosimilar) Antikörper (Extracellular Domain)

Reaktivität: Human BR, FACS, WB Wirt: Kaninchen Chimeric unconjugated Recombinant Antibody
Produktnummer ABIN5668061
  • Target Alle EGFR (Matuzumab Biosimilar) Produkte
    EGFR (Matuzumab Biosimilar)
    Antikörpertyp
    Recombinant Antibody
    Bindungsspezifität
    Extracellular Domain
    Reaktivität
    Human
    Wirt
    • 1
    • 1
    • 1
    Kaninchen
    Klonalität
    • 2
    • 1
    Chimeric
    Konjugat
    • 3
    Dieser EGFR (Matuzumab Biosimilar) Antikörper ist unkonjugiert
    Applikation
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Blocking Reagent (BR), Flow Cytometry (FACS), Western Blotting (WB)
    Spezifität
    Binds to human EGFR.
    Produktmerkmale

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Aufreinigung
    Purified antibody.
    Reinheit
    > 98 % as determined by SDS-PAGE
    Endotoxin-Niveau
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    The parental mouse antibody was generated by immunizing BALB/c mice intraperitoneally with A431 cells in phosphate buffered saline (PBS). Later on the humanzied version of the antibody was created by grafting CDRs of the murine antibody onto human constant regions.
    Isotyp
    IgG kappa
  • Applikationshinweise
    This antibody binds to human EGFR at a side distinct frm the antigen binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding (Schmiedel 2008).
    Kommentare

    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    EGFR (Matuzumab Biosimilar)
    Abstract
    EGFR (Matuzumab Biosimilar) Produkte
    Hintergrund
    ErbB-1, ERBB1, HER1, EGF, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EMD72000, mAb425, 425, mAb 425
    UniProt
    P00533
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