Rekombinanter EGFR (Matuzumab Biosimilar) Antikörper (Extracellular Domain)

Produktnummer ABIN5668061

Produktdetails anti-EGFR (Matuzumab Biosimilar) Antikörper

Target: EGFR (Matuzumab Biosimilar)

Antikörpertyp: Recombinant Antibody

Bindungsspezifität: Extracellular Domain

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser EGFR (Matuzumab Biosimilar) Antikörper ist unkonjugiert

Applikation: Blocking Reagent (BR), Flow Cytometry (FACS), Western Blotting (WB)

Spezifität: Binds to human EGFR.

Produktmerkmale:

OriginalSpeciesName: Human

OriginalFormat: IgG1

Aufreinigung: Purified antibody.

Reinheit: > 98 % as determined by SDS-PAGE

Endotoxin-Niveau: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: The parental mouse antibody was generated by immunizing BALB/c mice intraperitoneally with A431 cells in phosphate buffered saline (PBS). Later on the humanzied version of the antibody was created by grafting CDRs of the murine antibody onto human constant regions.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody binds to human EGFR at a side distinct frm the antigen binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding (Schmiedel 2008).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu EGFR (Matuzumab Biosimilar)

Target: EGFR (Matuzumab Biosimilar)

Abstract: EGFR (Matuzumab Biosimilar) Produkte

Hintergrund: ErbB-1, ERBB1, HER1, EGF, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EMD72000, mAb425, 425, mAb 425

UniProt: P00533