Rekombinanter RSV (Felvizumab Biosimilar) Antikörper
-
- Target Alle RSV (Felvizumab Biosimilar) Produkte
- RSV (Felvizumab Biosimilar)
- Antikörpertyp
- Recombinant Antibody
- Reaktivität
- Respiratory Syncytial Virus (RSV)
-
Wirt
-
Human
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser RSV (Felvizumab Biosimilar) Antikörper ist unkonjugiert
- Applikation
- ELISA, Functional Studies (Func)
- Spezifität
- This antibody is specific for the conserved fusion (F) protein of RSV.
- Produktmerkmale
-
OriginalSpeciesName: Human
OriginalFormat: IgG1
- Aufreinigung
- Purified antibody.
- Reinheit
- > 98 % as determined by SDS-PAGE
- Endotoxin-Niveau
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogen
- This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
- Klon
- RSHZ19
- Isotyp
- IgG1 kappa
-
-
- Applikationshinweise
- Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Buffer
- PBS with 0.02 % Proclin 300.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
-
- Target
- RSV (Felvizumab Biosimilar)
- Abstract
- RSV (Felvizumab Biosimilar) Produkte
- Substanzklasse
- Biosimilar
- Hintergrund
- SB 209763, respiratory syncytial virus
-