Rekombinanter ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper
Reaktivität: Human
FACS, ELISA, IHC
Wirt: Kaninchen
Chimeric
4D5-8
unconjugated
Recombinant Antibody
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- Target Alle ErbB2/Her2 (Trastuzumab Biosimilar) Produkte
- ErbB2/Her2 (Trastuzumab Biosimilar)
- Antikörpertyp
- Recombinant Antibody
- Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Chimeric
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Konjugat
- Dieser ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)
- Verwendungszweck
- Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)], Rabbit IgG, kappa
- Spezifität
- Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30 % of invasive breast cancers and 70 % of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.
- Produktmerkmale
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Original Species of Ab: Human
Original Format of Ab: IgG1
- Aufreinigung
- Protein A affinity purified
- Reinheit
- > 98 % as determined by SDS-PAGE
- Endotoxin-Niveau
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogen
- A431 cells (human epidermoid carcinoma) (over)expressing EGFR.
- Klon
- 4D5-8
- Isotyp
- IgG kappa
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anti-ErbB2/Her2 (Trastuzumab Biosimilar) antibody
Research Grade Reaktivität: Human FACS, ELISA Wirt: Humanized Monoclonal unconjugated Recombinant Antibody
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- Applikationshinweise
- This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).
- Kommentare
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This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- ErbB2/Her2 (Trastuzumab Biosimilar)
- Abstract
- ErbB2/Her2 (Trastuzumab Biosimilar) Produkte
- Substanzklasse
- Biosimilar
- Hintergrund
- CD340, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, p185HER2, EGFR
- UniProt
- P04626
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