Rekombinanter IL-6R (Tocilizumab Biosimilar) Antikörper

Produktnummer ABIN5668253

Produktdetails anti-IL-6R (Tocilizumab Biosimilar) Antikörper

Target: IL-6R (Tocilizumab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser IL-6R (Tocilizumab Biosimilar) Antikörper ist unkonjugiert

Applikation: ELISA, Inhibition Assay (InhA)

Spezifität: Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.

Produktmerkmale:

OriginalSpeciesName: Human

OriginalFormat: IgG1

Aufreinigung: Purified antibody.

Reinheit: > 98 % as determined by SDS-PAGE

Endotoxin-Niveau: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.

Klon: RhPM-1

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.

Kommentare:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Referenzen für anti-IL-6R (Tocilizumab Biosimilar) Antikörper (ABIN5668253)

Hsieh, Hsu, Chang, Lai: "IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells." in: Nature communications, Vol. 9, Issue 1, pp. 463, (2018) (PubMed).

Details zu IL-6R (Tocilizumab Biosimilar)

Target: IL-6R (Tocilizumab Biosimilar)

Abstract: IL-6R (Tocilizumab Biosimilar) Produkte

Synonyme: CD126 antikoerper, IL-6R-1 antikoerper, IL-6RA antikoerper, IL6Q antikoerper, IL6RA antikoerper, IL6RQ antikoerper, gp80 antikoerper, interleukin 6 receptor antikoerper, IL6R antikoerper

Substanzklasse: Biosimilar

Hintergrund: IL6R, MRA, atlizumab

UniProt: A0N0L5