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Rekombinanter IL-6R (Tocilizumab Biosimilar) Antikörper

Reaktivität: Human ELISA, InhA Wirt: Human Monoclonal RhPM-1 unconjugated Recombinant Antibody
Produktnummer ABIN5668253
  • Target Alle IL-6R (Tocilizumab Biosimilar) Produkte
    IL-6R (Tocilizumab Biosimilar)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    Human
    Wirt
    • 1
    • 1
    • 1
    Human
    Klonalität
    • 3
    Monoklonal
    Konjugat
    • 3
    Dieser IL-6R (Tocilizumab Biosimilar) Antikörper ist unkonjugiert
    Applikation
    • 3
    • 1
    • 1
    ELISA, Inhibition Assay (InhA)
    Spezifität
    Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
    Produktmerkmale

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Aufreinigung
    Purified antibody.
    Reinheit
    > 98 % as determined by SDS-PAGE
    Endotoxin-Niveau
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
    Klon
    RhPM-1
    Isotyp
    IgG1 kappa
  • Applikationshinweise
    Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
    Kommentare

    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Hsieh, Hsu, Chang, Lai: "IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells." in: Nature communications, Vol. 9, Issue 1, pp. 463, (2018) (PubMed).

  • Target
    IL-6R (Tocilizumab Biosimilar)
    Abstract
    IL-6R (Tocilizumab Biosimilar) Produkte
    Synonyme
    CD126 antikoerper, IL-6R-1 antikoerper, IL-6RA antikoerper, IL6Q antikoerper, IL6RA antikoerper, IL6RQ antikoerper, gp80 antikoerper, interleukin 6 receptor antikoerper, IL6R antikoerper
    Substanzklasse
    Biosimilar
    Hintergrund
    IL6R, MRA, atlizumab
    UniProt
    A0N0L5
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