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Rekombinanter IL-6R (Tocilizumab Biosimilar) Antikörper

Reaktivität: Human ELISA, InhA Wirt: Kaninchen Monoclonal RhPM-1 unconjugated Recombinant Antibody
Produktnummer ABIN5668254
  • Target Alle IL-6R (Tocilizumab Biosimilar) Produkte
    IL-6R (Tocilizumab Biosimilar)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    Human
    Wirt
    • 1
    • 1
    • 1
    Kaninchen
    Klonalität
    • 3
    Monoklonal
    Konjugat
    • 3
    Dieser IL-6R (Tocilizumab Biosimilar) Antikörper ist unkonjugiert
    Applikation
    • 3
    • 1
    • 1
    ELISA, Inhibition Assay (InhA)
    Spezifität
    Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
    Produktmerkmale

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Aufreinigung
    Purified antibody.
    Reinheit
    > 98 % as determined by SDS-PAGE
    Endotoxin-Niveau
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
    Klon
    RhPM-1
    Isotyp
    IgG kappa
  • Applikationshinweise
    Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
    Kommentare

    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    IL-6R (Tocilizumab Biosimilar)
    Abstract
    IL-6R (Tocilizumab Biosimilar) Produkte
    Synonyme
    CD126 antikoerper, IL-6R-1 antikoerper, IL-6RA antikoerper, IL6Q antikoerper, IL6RA antikoerper, IL6RQ antikoerper, gp80 antikoerper, interleukin 6 receptor antikoerper, IL6R antikoerper
    Substanzklasse
    Biosimilar
    Hintergrund
    IL6R, MRA, atlizumab
    UniProt
    A0N0L5
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