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NONO Antikörper (AA 21-120)

NONO Reaktivität: Human, Ziege WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5675600
  • Target Alle NONO Antikörper anzeigen
    NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
    Bindungsspezifität
    • 14
    • 13
    • 8
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 21-120
    Reaktivität
    • 77
    • 38
    • 34
    • 14
    • 13
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 1
    Human, Ziege
    Wirt
    • 70
    • 6
    • 2
    Kaninchen
    Klonalität
    • 63
    • 15
    Polyklonal
    Konjugat
    • 38
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NONO Antikörper ist unkonjugiert
    Applikation
    • 60
    • 35
    • 26
    • 16
    • 13
    • 13
    • 13
    • 8
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Ziege, Human
    Homologie
    Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NMT55
    Isotyp
    IgG
    Top Product
    Discover our top product NONO Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
    Andere Bezeichnung
    NMT55 (NONO Produkte)
    Synonyme
    NMT55 antikoerper, NRB54 antikoerper, P54 antikoerper, P54NRB antikoerper, nmt55 antikoerper, nrb54 antikoerper, p54nrb antikoerper, xp54nrb antikoerper, AA407051 antikoerper, AV149256 antikoerper, nonA antikoerper, non-POU domain containing octamer binding antikoerper, non-POU domain containing, octamer-binding antikoerper, non-POU domain containing, octamer binding L homeolog antikoerper, non-POU-domain-containing, octamer binding protein antikoerper, NONO antikoerper, Nono antikoerper, nono.L antikoerper
    Hintergrund

    Synonyms: Non-POU domain-containing octamer-binding protein, NONO, 54 kDa nuclear RNA- and DNA-binding protein, 55 kDa nuclear protein, DNA-binding p52/p100 complex, 52 kDa subunit, NMT55, p54(nrb), p54nrb, NRB54

    Background: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity). Involved in pre-mRNA splicing, probably as an heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. Nono is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.

    Gen-ID
    4841
    UniProt
    Q15233
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