Isocitrate Dehydrogenase Antikörper

Produktnummer ABIN568270

Produktdetails anti-Isocitrate Dehydrogenase Antikörper

Target: Isocitrate Dehydrogenase (IDH)

Reaktivität: Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Isocitrate Dehydrogenase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Dot Blot (DB), Immunodiffusion (ID), Radioimmunoassay (RIA)

Aufreinigung: Ammonium Sulphate Precipitation and Ion Exchange Chromatography

Immunogen: Isocitrate Dehydrogenase isolated and purified from Porcine heart. Freund’s complete adjuvant is used in the first step of the immunization procedure.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore by adding 1.0 mL sterile distilled water

Konzentration: 10 mg/mL

Buffer: PBS, pH 7.2 without preservatives and foreign proteins

Konservierungsmittel: Without preservative

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody lyophilized at 2-8 °C and reconstituted at 2-8 °C for one week or (in aliquots) at -20 °C for longer. If a slight precipitation occurs upon storage, this should be removed by centrifugation.

Details zu Isocitrate Dehydrogenase

Target: Isocitrate Dehydrogenase (IDH)

Andere Bezeichnung: Isocitrate Dehydrogenase / IDH (IDH Produkte)

Synonyme: CG7176 antikoerper, CT22171 antikoerper, Dmel\\CG7176 antikoerper, IDH antikoerper, IDH-NADP antikoerper, Idh-NADP antikoerper, idh antikoerper, isocitrate dehydrogenase antikoerper, l(3)L3852 antikoerper, F20D21.16 antikoerper, F20D21_16 antikoerper, SMU.672 antikoerper, icd antikoerper, Isocitrate dehydrogenase antikoerper, isocitrate dehydrogenase antikoerper, isocitrate dehydrogenase, NADP-dependent antikoerper, Monomeric isocitrate dehydrogenase antikoerper, ankyrin repeat domain 26-like antikoerper, Idh antikoerper, ICDH antikoerper, idh antikoerper, icd antikoerper, SSO_RS10660 antikoerper, JK_RS08640 antikoerper, LOC618625 antikoerper

Hintergrund: Isocitrate dehydrogenase is an enzyme involved in the citric acid cycle. It is 416 amino acids long with a molecular weight of approximately 45 kDa. Isocitrate dehydrogenase enzymes catalyze the oxidative decarboxylation of isocitrate to produce alfa ketoglutarate. The human genome has 5 IDH genes coding for 3 IDH enzymes. The IDH1 and IDH2 require nicotinamide adeninedinucleotide phosphate (NADP) as co-substrate, whereas IDH3 require nicotinamide adenine dinucleotide (NAD). The IDH2 and 3 are localized in mitochondria and are actively involved in the citric acid cycle (TCA) for energy production in contrast, IDH1 is localized in cytoplasm and peroxisomes where it generates NADPH, reduced form of NADP for biosynthetic and other types of reaction. Since alfa KG and NADPH both are intermediately substrate for a number of cellular process, which allows the possibility of oncogenic or tumor suppressive activities of IDH1.Synonyms: Cytosolic NADP-isocitrate dehydrogenase, ICDH, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD, cytoplasmic Isocitrate dehydrogenase [NADP]

Gen-ID: 9823

UniProt: P20304