TBC1D4 Antikörper (AA 574-712)

Produktnummer ABIN5684096

Produktdetails anti-TBC1D4 Antikörper

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Bindungsspezifität: AA 574-712

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TBC1D4 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Verwendungszweck: TBC1D4 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human TBC1D4 (AA: 574-712) expressed in E. Coli.

Klon: 8A11A2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu TBC1D4

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Andere Bezeichnung: TBC1D4 (TBC1D4 Produkte)

Synonyme: AS160 antikoerper, 5930406J04Rik antikoerper, A930035N22 antikoerper, AV295684 antikoerper, As160 antikoerper, RGD1561609 antikoerper, TBC1 domain family member 4 antikoerper, TBC1 domain family, member 4 antikoerper, TBC1D4 antikoerper, Tbc1d4 antikoerper

Hintergrund:

Description: This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aliases: AS160, NIDDM5

Molekulargewicht: 146.5kDa

Gen-ID: 9882

HGNC: 23495

UniProt: O60343