BNIP3 Antikörper
-
- Target Alle BNIP3 Antikörper anzeigen
- BNIP3 (BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3))
- Reaktivität
- Human, Maus, Ratte
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser BNIP3 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Marke
- Picoband™
- Sequenz
- KEFLFKHPKR TATLSMRNTS VMKK
- Kreuzreaktivität (Details)
- No cross reactivity with other proteins.
- Produktmerkmale
- Rabbit IgG polyclonal antibody for BNIP3 detection. Tested with WB in Human,Mouse,Rat.
- Immunogen
- A synthetic peptide corresponding to a sequence of human BNIP3 (KEFLFKHPKRTATLSMRNTSVMKK).
- Top Product
- Discover our top product BNIP3 Primärantikörper
-
-
- Applikationshinweise
-
Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
Application Details: Western blot, 0.1-0.5 μg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
-
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
-
-
MicroRNA-145 induces apoptosis of glioma cells by targeting BNIP3 and Notch signaling." in: Oncotarget, Vol. 8, Issue 37, pp. 61510-61527, (2017) (PubMed).
: "
-
MicroRNA-145 induces apoptosis of glioma cells by targeting BNIP3 and Notch signaling." in: Oncotarget, Vol. 8, Issue 37, pp. 61510-61527, (2017) (PubMed).
-
- Target
- BNIP3 (BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3))
- Andere Bezeichnung
- BNIP3 (BNIP3 Produkte)
- Synonyme
- NIP3 antikoerper, Nip3 antikoerper, BCL2 interacting protein 3 antikoerper, BCL2/adenovirus E1B interacting protein 3 antikoerper, BNIP3 antikoerper, Bnip3 antikoerper
- Hintergrund
-
Synonyms: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, BNIP3, NIP3
Background: The Bcl-2 nineteen kilodalton interacting protein 3 (BNIP3 or NIP3), is a hypoxia-inducible proapoptotic member of the Bcl-2 family that induces cell death by associating with the mitochondria. BNIP3, expressed in skeletal muscle and in the brain at low levels, is primarily localized to the nucleus of glial cells of the normal human brain, as well as in the malignant glioma cell line U251. BNIP3 expression in the cytoplasm increases and localizes with the mitochondria, contributing to induction of cell death. Cellular protein BNIP3 interacts with E1B-19K, BCL-2, BCL-xL, and EBV-BHRF1. BNIP3 contains Bcl-2 homology 3 (BH3) domain and COOH-terminal transmembrane (TM) domain. The BH3 domain of BNIP3 mediates Bcl-2/Bcl-X(L) heterodimerization and confers pro-apoptotic activity, whereas the TM domain is critical for homodimerization, pro-apoptotic function, and mitochondrial targeting.
- UniProt
- Q12983
- Pathways
- Autophagie, Brown Fat Cell Differentiation
-