LIF Antikörper (AA 24-203)

Produktnummer ABIN5692888

Produktdetails anti-LIF Antikörper

Target: LIF (Leukemia Inhibitory Factor (LIF))

Bindungsspezifität: AA 24-203

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LIF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Marke: Picoband™

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for LIF detection. Tested with WB, ELISA(Cap) in Human,Mouse,Rat.

Immunogen: E. coli-derived mouse LIF recombinant protein (Position: S24-F203).

Anwendungsinformationen

Applikationshinweise:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Application Details: Western blot, 0.1-0.5 μg/mL
ELISA(Cap), 1-5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-LIF Antikörper (ABIN5692888)

Zhang, Liu, Liu, Zhou, Song, Cao, An: "miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression." in: PLoS ONE, Vol. 12, Issue 7, pp. e0179783, (2017) (PubMed).

Dong, Sui, Huang, Wang, Hu, Xiong, Wang, Zhang: "MicroRNA-223-3p suppresses leukemia inhibitory factor expression and pinopodes formation during embryo implantation in mice." in: American journal of translational research, Vol. 8, Issue 2, pp. 1155-63, (2016) (PubMed).

Hu, Feng, Tang, Zhu, Lin, Yu: "LIF upregulates expression of NK-1R in NHBE cells." in: Mediators of inflammation, Vol. 2006, Issue 5, pp. 84829, (2007) (PubMed).

Details zu LIF

Target: LIF (Leukemia Inhibitory Factor (LIF))

Andere Bezeichnung: Lif (LIF Produkte)

Synonyme: CDF antikoerper, DIA antikoerper, HILDA antikoerper, MLPLI antikoerper, LIF, interleukin 6 family cytokine antikoerper, leukemia inhibitory factor antikoerper, LIF antikoerper, Lif antikoerper

Hintergrund:

Synonyms: Leukemia inhibitory factor, LIF, Differentiation-stimulating factor, D factor, Lif

Background: LIF is a pleiotropic cytokine produced at the maternal-fetal interface which has been shown to play an essential role in implantation in mice. This gene is mapped to 22q11-q12.2, between the Philadelphia translocation BCR gene and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF is produced in high amounts by the human endometrium and the trophoblast itself, and LIF receptors are present on cytotrophoblast cells. LIF could, thus, play a role in modulating HLA-G production and immune tolerance at the maternal-fetal interface.

UniProt: P09056

Pathways: JAK-STAT Signalweg, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Stem Cell Maintenance, Growth Factor Binding