CTNNA1 Antikörper (AA 143-292) (DyLight 488)
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- Target Alle CTNNA1 Antikörper anzeigen
- CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
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Bindungsspezifität
- AA 143-292
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CTNNA1 Antikörper ist konjugiert mit DyLight 488
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Applikation
- Flow Cytometry (FACS)
- Kreuzreaktivität (Details)
- No cross reactivity with other proteins.
- Produktmerkmale
- Rabbit IgG Polyclonal Anti-Human CTNNA1 Antibody DyLight® 488 Conjugated, Flow Validated.
- Immunogen
- E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292). Human CTNNA1 shares 98% amino acid (aa) sequence identity with mouse CTNNA1.
- Top Product
- Discover our top product CTNNA1 Primärantikörper
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- Applikationshinweise
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Application Details: Flow Cytometry, 1-3 μg/1x106 cells
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- At 2-8°C for one year. Protect from light. Do not freeze.
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TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).
: "Prognostic and clinicopathological features of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and cyclin D1 expression in human esophageal squamous cell carcinoma." in: World journal of gastroenterology, Vol. 10, Issue 22, pp. 3235-9, (2005) (PubMed).
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TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).
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- Target
- CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
- Andere Bezeichnung
- CTNNA1 (CTNNA1 Produkte)
- Synonyme
- CAP102 antikoerper, 2010010M04Rik antikoerper, AA517462 antikoerper, AI988031 antikoerper, Catna1 antikoerper, CG17947 antikoerper, CT39986 antikoerper, Dalpha-Cat antikoerper, Dalpha-cat antikoerper, DalphaC antikoerper, Dalphacat antikoerper, Dmcatp antikoerper, Dmel\\CG17947 antikoerper, a-Cat antikoerper, a-cat antikoerper, alpha-CAT antikoerper, alpha-cat antikoerper, alpha-catenin antikoerper, alpha-ctn antikoerper, alphaCAT antikoerper, alphaCat antikoerper, alphacat antikoerper, Alpha-Cat antikoerper, dgri_GLEANR_3829 antikoerper, DgriGH19548 antikoerper, GH19548 antikoerper, ctnna antikoerper, cap102 antikoerper, catna1 antikoerper, ctnna1 antikoerper, catenin alpha 1 antikoerper, catenin (cadherin associated protein), alpha 1 antikoerper, alpha Catenin antikoerper, catenin alpha-1 antikoerper, catenin (cadherin-associated protein), alpha 1 antikoerper, catenin alpha 1 S homeolog antikoerper, CTNNA1 antikoerper, Ctnna1 antikoerper, alpha-Cat antikoerper, Dgri\alpha-Cat antikoerper, Tsp_10127 antikoerper, ctnna1 antikoerper, ctnna1.S antikoerper
- Hintergrund
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Synonyms: Catenin alpha-1, Alpha E-catenin, Cadherin-associated protein, Renal carcinoma antigen NY-REN-13, CTNNA1
Tissue Specificity: Expressed ubiquitously in normal tissues.
Background: CTNNA1, also known as Catenin alpha-1 or Catenin (cadherin-associated protein), alpha 1, is a protein that in humans is encoded by the CTNNA1 gene. It is mapped to 5q31.2. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1.
- UniProt
- P35221
- Pathways
- Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location
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