VRK2 Antikörper
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- Target Alle VRK2 Antikörper anzeigen
- VRK2 (Vaccinia Related Kinase 2 (VRK2))
- Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser VRK2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- Immunogen
- vaccinia related kinase 2
- Isotyp
- IgG
- Top Product
- Discover our top product VRK2 Primärantikörper
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- Applikationshinweise
- WB :1:500-1:5000,IP:1:200-1:2000
- Kommentare
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K-562 cells were subjected to SDS PAGE followed by western blot with FNab09452(VRK2 antibody) at dilution of 1:500
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze / thaw cycles.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- VRK2 (Vaccinia Related Kinase 2 (VRK2))
- Andere Bezeichnung
- VRK2 (VRK2 Produkte)
- Synonyme
- 2810003O05Rik antikoerper, AI447698 antikoerper, vaccinia related kinase 2 antikoerper, VRK2 antikoerper, Vrk2 antikoerper
- Hintergrund
- Synonyms:Vaccinia related kinase 2, VRK2 Background:Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta(IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase(MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant. Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.
- Molekulargewicht
- 151kDa
- Gen-ID
- 7444
- UniProt
- Q86Y07
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