MAGOH Antikörper
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- Target Alle MAGOH Antikörper anzeigen
- MAGOH (Mago-Nashi Homolog (MAGOH))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MAGOH Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Immunogen
- mago-nashi homolog, proliferation-associated (Drosophila)
- Isotyp
- IgG
- Top Product
- Discover our top product MAGOH Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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K-562 cells were subjected to SDS PAGE followed by western blot with FNab04954( MAGOH Antibody) at dilution of 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze / thaw cycles.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- MAGOH (Mago-Nashi Homolog (MAGOH))
- Andere Bezeichnung
- MAGOH (MAGOH Produkte)
- Synonyme
- MAGOH1 antikoerper, MAGOHA antikoerper, Mago-m antikoerper, Mos2 antikoerper, MAGOH antikoerper, zgc:112220 antikoerper, mago antikoerper, xl-mago antikoerper, CG9401 antikoerper, Dm MGN antikoerper, DmMago antikoerper, Dmel\CG9401 antikoerper, MGN antikoerper, Mago antikoerper, Magoh antikoerper, l(2)57Ca antikoerper, mgn antikoerper, magoh antikoerper, mago homolog, exon junction complex core component antikoerper, protein mago nashi homolog antikoerper, mago homolog, exon junction complex core component L homeolog antikoerper, mago nashi antikoerper, MAGOH antikoerper, Magoh antikoerper, LOC736868 antikoerper, magoh antikoerper, magoh.L antikoerper, mago antikoerper, LOC106584057 antikoerper
- Hintergrund
- Synonyms:MAGOHA Background:Core component of the splicing-dependent multiprotein exon junction complex(EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay(NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X(and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly.
- Molekulargewicht
- 17 kDa
- Gen-ID
- 4116
- UniProt
- P61326
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