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MAML3 Antikörper

MAML3 Reaktivität: Human FACS, IF, IHC (p) Wirt: Maus Monoclonal MAML3-1303 unconjugated
Produktnummer ABIN5707997
  • Target Alle MAML3 Antikörper anzeigen
    MAML3 (Mastermind-Like 3 (MAML3))
    Reaktivität
    • 43
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 29
    • 14
    Maus
    Klonalität
    • 30
    • 13
    Monoklonal
    Konjugat
    • 22
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAML3 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 13
    • 13
    • 12
    • 11
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    Purified
    Reinheit
    Protein G affinity chromatography
    Immunogen
    A human full length recombinant protein was used as the immunogen for this MAML3 antibody.
    Klon
    MAML3-1303
    Isotyp
    IgG1
    Top Product
    Discover our top product MAML3 Primärantikörper
  • Applikationshinweise
    The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MAML3 antibody to be titered up or down for optimal performance.\. FACS: 0.5-1 μg/10^6 cells,Immunofluorescence: 1-2 μg/mL,Immunohistochemistry (FFPE): 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    1 mg/mL in 1X PBS, BSA free, sodium azide free
    Konservierungsmittel
    Azide free
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store the MAML3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • Target
    MAML3 (Mastermind-Like 3 (MAML3))
    Andere Bezeichnung
    MAML3 (MAML3 Produkte)
    Synonyme
    AV234550 antikoerper, BC049812 antikoerper, Mam-2 antikoerper, mKIAA1816 antikoerper, Glrp1 antikoerper, CAGH3 antikoerper, ERDA3 antikoerper, GDN antikoerper, MAM-2 antikoerper, MAM2 antikoerper, TNRC3 antikoerper, mastermind like 3 (Drosophila) antikoerper, mastermind-like transcriptional coactivator 3 antikoerper, mastermind like transcriptional coactivator 3 antikoerper, Maml3 antikoerper, MAML3 antikoerper
    Hintergrund
    Mastermind-like 3 is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch 1-4 proteins. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, its upregulation is thought to be involved in oncogenesis.
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