RUNX1T1 Antikörper

Produktnummer ABIN5708488

Produktdetails anti-RUNX1T1 Antikörper

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RUNX1T1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity purified

Immunogen: A recombinant human protein corresponding to amino acids T335-D510 was used as the immunogen for the RUNX1T1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the RUNX1T1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL, IHC (FFPE): 1-2 μg/mL, Direct ELISA: 0.1-0.5 μg/mL (human recombinant protein)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the RUNX1T1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu RUNX1T1

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Andere Bezeichnung: RUNX1T1 (RUNX1T1 Produkte)

Synonyme: MTG8 antikoerper, si:ch211-232j17.1 antikoerper, wu:fi14b07 antikoerper, zgc:154044 antikoerper, AML1T1 antikoerper, CBFA2T1 antikoerper, CDR antikoerper, ETO antikoerper, ZMYND2 antikoerper, Cbfa2t1h antikoerper, Cbfa2t1 antikoerper, runt-related transcription factor 1; translocated to, 1 (cyclin D-related) antikoerper, RUNX1 translocation partner 1 L homeolog antikoerper, RUNX1 translocation partner 1 antikoerper, runx1t1 antikoerper, runx1t1.L antikoerper, RUNX1T1 antikoerper, Runx1t1 antikoerper

Hintergrund: Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene. This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

UniProt: Q06455