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CaMKIIalpha/delta Antikörper (Thr286)

Reaktivität: Human, Maus, Ratte IF, WB, IHC (p), ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5960662
  • Target Alle CaMKIIalpha/delta Produkte
    CaMKIIalpha/delta
    Bindungsspezifität
    • 2
    • 1
    • 1
    • 1
    • 1
    Thr286
    Reaktivität
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 6
    Kaninchen
    Klonalität
    • 6
    Polyklonal
    Konjugat
    • 6
    Dieser CaMKIIalpha/delta Antikörper ist unkonjugiert
    Applikation
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
    Spezifität
    CAMK2A,CAMKA,KIAA0968,Calcium/calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,CaMK-II subunit alpha,CAMK2D,CAMKD,Calcium/calmodulin-dependent protein kinase type II subunit delta,CaM kinase II
    Aufreinigung
    Affinity purification
    Immunogen
    Synthesized peptide derived from human CaMKIIalpha/delta around the non-phosphorylation site of Thr286.
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    CaMKIIalpha/delta
    Abstract
    CaMKIIalpha/delta Produkte
    Hintergrund
    The product of CAMK2A belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) is a Protein Coding gene. Diseases associated with CAMK2A include Conduct Disorder. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2D. The product of CAMK2D belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta) is a Protein Coding gene. Diseases associated with CAMK2D include Dilated Cardiomyopathy and Cardiomyopathy. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2B.
    Molekulargewicht
    54kDa
    Gen-ID
    815, 817
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