Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

IGF2R Antikörper (PE)

IGF2R Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal MEM-238 PE
Produktnummer ABIN609650
  • Target Alle IGF2R Antikörper anzeigen
    IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
    Reaktivität
    • 88
    • 36
    • 19
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    Human, Non-Human Primate
    Wirt
    • 68
    • 22
    Maus
    Klonalität
    • 67
    • 23
    Monoklonal
    Konjugat
    • 47
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IGF2R Antikörper ist konjugiert mit PE
    Applikation
    • 35
    • 32
    • 28
    • 23
    • 14
    • 13
    • 13
    • 11
    • 8
    • 6
    • 3
    • 2
    • 2
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The antibody MEM-238 recognizes an extracellular epitope between amino acids 192-697 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10 % in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.
    Kreuzreaktivität (Details)
    Human, Non-Human Primates
    Aufreinigung
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    Recombinant Vaccinia virus encoding CD222.
    Klon
    MEM-238
    Isotyp
    IgG1
    Top Product
    Discover our top product IGF2R Primärantikörper
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. Extracellular and intracellular staining.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Schatzlmaier, Supper, Göschl, Zwirzitz, Eckerstorfer, Ellmeier, Huppa, Stockinger: "Rapid multiplex analysis of lipid raft components with single-cell resolution." in: Science signaling, Vol. 8, Issue 395, pp. rs11, (2015) (PubMed).

    Leksa, Godár, Cebecauer, Hilgert, Breuss, Weidle, Horejsí, Binder, Stockinger: "The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40575-82, (2002) (PubMed).

  • Target
    IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
    Andere Bezeichnung
    CD222 (IGF2R Produkte)
    Synonyme
    CD222 antikoerper, CIMPR antikoerper, M6P-R antikoerper, MPR1 antikoerper, MPRI antikoerper, AI661837 antikoerper, CI-MPR antikoerper, M6P/IGF2R antikoerper, Mpr300 antikoerper, mpri antikoerper, cd222 antikoerper, cimpr antikoerper, m6p-r antikoerper, insulin like growth factor 2 receptor antikoerper, insulin-like growth factor 2 receptor antikoerper, IGF2R antikoerper, Igf2r antikoerper, igf2r antikoerper
    Hintergrund
    Insulin like growth factor 2 receptorprovided,CD222 (CIMPR, cation-independent mannose 6-phosphate receptor, IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10 % of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.,IGF2R, MPR1, CIMPR, MPR300, M6P-R
    Gen-ID
    3482
    UniProt
    P11717
Sie sind hier:
Kundenservice