AVPR2 Antikörper (AA 232-371)
-
- Target Alle AVPR2 Antikörper anzeigen
- AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))
-
Bindungsspezifität
- AA 232-371
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser AVPR2 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Sequenz
- IHASLVPGPS ERPGGRRRGR RTGSPGEGAH VSAAVAKTVR MTLVIVVVYV LCWAPFFLVQ LWAAWDPEAP LEGAPFVLLM LLASLNSCTN PWIYASFSSS VSSELRSLLC CARGRTPPSL GPQDESCTTA SSSLAKDTSS
- Kreuzreaktivität
- Human
- Produktmerkmale
- Polyclonal Antibodies
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 232-371 of human AVPR2 (NP_000045.1).
- Isotyp
- IgG
- Top Product
- Discover our top product AVPR2 Primärantikörper
-
-
- Applikationshinweise
- WB,1:500 - 1:2000
- Kommentare
-
HIGH QUALITY
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))
- Andere Bezeichnung
- AVPR2 (AVPR2 Produkte)
- Synonyme
- AVPR2 antikoerper, ADHR antikoerper, DI1 antikoerper, DIR antikoerper, DIR3 antikoerper, NDI antikoerper, V2R antikoerper, ND1 antikoerper, VPV2R antikoerper, arginine vasopressin receptor 2 antikoerper, AVPR2 antikoerper, Avpr2 antikoerper
- Hintergrund
- This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.,AVPR2,ADHR,DI1,DIR,DIR3,NDI,V2R,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Neuroscience,AVPR2
- Molekulargewicht
- 33 kDa/40 kDa
- Gen-ID
- 554
- UniProt
- P30518
- Pathways
- cAMP Metabolic Process
-