Caspase 8 Antikörper (AA 1-479)

Produktnummer ABIN6137970

Produktdetails anti-Caspase 8 Antikörper

Target: Caspase 8 (CASP8)

Bindungsspezifität: AA 1-479

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequenz: MDFSRNLYDI GEQLDSEDLA SLKFLSLDYI PQRKQEPIKD ALMLFQRLQE KRMLEESNLS FLKELLFRIN RLDLLITYLN TRKEEMEREL QTPGRAQISA YRVMLYQISE EVSRSELRSF KFLLQEEISK CKLDDDMNLL DIFIEMEKRV ILGEGKLDIL KRVCAQINKS LLKIINDYEE FSKGEELCGV MTISDSPREQ DSESQTLDKV YQMKSKPRGY CLIINNHNFA KAREKVPKLH SIRDRNGTHL DAGALTTTFE ELHFEIKPHD DCTVEQIYEI LKIYQLMDHS NMDCFICCIL SHGDKGIIYG TDGQEAPIYE LTSQFTGLKC PSLAGKPKVF FIQACQGDNY QKGIPVETDS EEQPYLEMDL SSPQTRYIPD EADFLLGMAT VNNCVSYRNP AEGTWYIQSL CQSLRERCPR GDDILTILTE VNYEVSNKDD KKNMGKQMPQ PTFTLRKKLV FPSD

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-479 of human Caspase-8 (NP_001073593.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-Caspase 8 Antikörper (ABIN6137970)

Chen, Deng, Gan, Li, Huang, Lu, Wei, Su, Luo, Zou, Hong, Cao, Liu, Chi: "NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma." in: Molecular neurodegeneration, Vol. 15, Issue 1, pp. 26, (2020) (PubMed).

Song, Ma, Lu, Zhou, Zhao, Ai, Wei, Lin, Wang, Yan, Jiao: "The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced islet β-cell dysfunction and apoptosis." in: Experimental cell research, Vol. 382, Issue 1, pp. 111467, (2020) (PubMed).

Kong, Liu, Zhou, Hou, He, Li, Miao, Yang: "Downregulation of METTL14 increases apoptosis and autophagy induced by cisplatin in pancreatic cancer cells." in: The international journal of biochemistry & cell biology, Vol. 122, pp. 105731, (2020) (PubMed).

Zhao, Zhu, Bu, Zhou, Bai, Guo, Gao, Lu: "Triggering apoptosis by oroxylin A through caspase-8 activation and p62/SQSTM1 proteolysis." in: Redox biology, Vol. 29, pp. 101392, (2020) (PubMed).

Zhou, Li, Han, Feng, Liu, Chen, Liu, Zhao, Jin: "Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway." in: Investigational new drugs, Vol. 38, Issue 1, pp. 50-59, (2020) (PubMed).

Chen, Fang, Chen, Yang, Zhou, Mao, Xia, Jin, Li, You, Wang, Lei, He, Hu: "Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke." in: Cell death & disease, Vol. 10, Issue 7, pp. 487, (2020) (PubMed).

Hu, Li, Yu, Liu, Wang, Qing, Wang, Wang, Zhu, Xu, Tan, Guo, Hui: "GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis." in: Free radical biology & medicine, Vol. 145, pp. 237-249, (2020) (PubMed).

Jin, Shi, Liu, Chen, Yang: "Xanthones from the Bark of Garcinia xanthochymus and the Mechanism of Induced Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells via the Mitochondrial Pathway." in: International journal of molecular sciences, Vol. 20, Issue 19, (2020) (PubMed).

Yu, Ye, Li, Zhan, Liu, Yan, Fang, Xie, Zhang, Chen, Ding, Chen: "Histone methyltransferase SETDB1 promotes colorectal cancer proliferation through the STAT1-CCND1/CDK6 axis." in: Carcinogenesis, Vol. 41, Issue 5, pp. 678-688, (2020) (PubMed).

Liu, Wei, Fang, Li, Li: "Giardia duodenalis induces extrinsic pathway of apoptosis in intestinal epithelial cells through activation of TNFR1 and K63 de-ubiquitination of RIP1 in vitro." in: Microbial pathogenesis, Vol. 149, pp. 104315, (2020) (PubMed).

Chen, Wei, Yang, Guo, Guo, Zhou: "Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 143, pp. 111517, (2020) (PubMed).

Yu, Zhu, Wang, Li, Hu, Qing, Wang, Wang, Wang, Xu, Guo, Hui: "LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK-eIF2α-ATF4-CHOP axis." in: Acta pharmacologica Sinica, (2020) (PubMed).

Chen, Gan, Li, Gu, Liu, Deng, Wang, Hong, Hu, Su, Chi: "NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye." in: The ocular surface, Vol. 18, Issue 4, pp. 783-794, (2020) (PubMed).

Cheng, Qin, Huang, Zhou, Xiong, Zhao, Zhang, Yu: "Cytokeratin 18 regulates the transcription and alternative splicing of apoptotic‑related genes and pathways in HeLa cells." in: Oncology reports, Vol. 42, Issue 1, pp. 301-312, (2019) (PubMed).

Zuo, Kong, Wang, Liu, Wang, Wan, Yan, Zhang, Tang, Zhang, Lyu, Li, Shan, Qian, Shen, Yu: "CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyte apoptosis through m-calpain." in: EMBO molecular medicine, Vol. 10, Issue 3, (2018) (PubMed).

Xu, Li, Jiang, Feng, Wu, Cai, Zhang, Huang, Sealy, Iqbal, Li: "Antiviral Immunotoxin Against Bovine herpesvirus-1: Targeted Inhibition of Viral Replication and Apoptosis of Infected Cell." in: Frontiers in microbiology, Vol. 9, pp. 653, (2018) (PubMed).

Cai, Lv, Kaldybayeva, Zhamilya, Wu, Wu: "15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo." in: Frontiers in pharmacology, Vol. 9, pp. 25, (2018) (PubMed).

Details zu Caspase 8

Target: Caspase 8 (CASP8)

Andere Bezeichnung: Casp8 (CASP8 Produkte)

Synonyme: casp8-A antikoerper, xCaspase-8 antikoerper, casp8 antikoerper, CASP8 antikoerper, CASP-8 antikoerper, FLICE antikoerper, MACH antikoerper, Mch5 antikoerper, ALPS2B antikoerper, CAP4 antikoerper, Casp-8 antikoerper, MCH5 antikoerper, caspase-8 antikoerper, zgc:92075 antikoerper, caspase 8 L homeolog antikoerper, death related ced-3/Nedd2-like protein antikoerper, caspase 8 antikoerper, caspase-8 antikoerper, caspase-8-like antikoerper, caspase 8, apoptosis-related cysteine peptidase antikoerper, casp8.L antikoerper, LOC661095 antikoerper, CASP8 antikoerper, LOC5563818 antikoerper, casp8 antikoerper, LOC100222284 antikoerper, Casp8 antikoerper

Hintergrund: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.,ALPS2B,CAP4,Casp-8,FLICE,MACH,MCH5,Caspase 8,CASP8,Caspase-8,caspase-8,Cancer,Invasion and Metastasis,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Caspases,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Ubiquitin,Death Receptor Signaling Pathway,Endocrine & Metabolism,Immunology & Inflammation,Toll-like Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Casp8

Molekulargewicht: 25-32 kDa/45- 61 kDa

Gen-ID: 841

UniProt: Q14790

Pathways: Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades