col4a1 antikoerper, wu:fc02g11 antikoerper, HANAC antikoerper, ICH antikoerper, POREN1 antikoerper, arresten antikoerper, Bru antikoerper, Col4a-1 antikoerper, Del(8)44H antikoerper, Raw antikoerper, Svc antikoerper, collagen, type IV, alpha 5 (Alport syndrome) antikoerper, collagen type IV alpha 1 chain antikoerper, collagen, type IV, alpha 1 antikoerper, col4a5 antikoerper, COL4A1 antikoerper, Col4a1 antikoerper
Hintergrund
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.,COL4A1,BSVD,RATOR,Stem Cells,COL4A1