CD35 Antikörper (AA 420-550)

Produktnummer ABIN6138990

Produktdetails anti-CD35 Antikörper

Target: CD35 (CR1) (Complement Component Receptor 1 (CD35) (CR1))

Bindungsspezifität: AA 420-550

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD35 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: FCPSPPVIPN GRHTGKPLEV FPFGKTVNYT CDPHPDRGTS FDLIGESTIR CTSDPQGNGV WSSPAPRCGI LGHCQAPDHF LFAKLKTQTN ASDFPIGTSL KYECRPEYYG RPFSITCLDN LVWSSPKDVC K

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 420-550 of human CD35/CD35/CR1 (NP_000642.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CD35

Target: CD35 (CR1) (Complement Component Receptor 1 (CD35) (CR1))

Andere Bezeichnung: CR1 (CR1 Produkte)

Synonyme: C3BR antikoerper, C4BR antikoerper, CD35 antikoerper, KN antikoerper, C3DR antikoerper, CD21 antikoerper, Cr-1 antikoerper, Cr-2 antikoerper, Cr1 antikoerper, CR1-L antikoerper, CR2 antikoerper, CR1 antikoerper, complement C3b/C4b receptor 1 (Knops blood group) antikoerper, complement receptor 2 antikoerper, complement component (3d/Epstein Barr virus) receptor 2 antikoerper, complement receptor type 1 antikoerper, CR1 antikoerper, Cr2 antikoerper, CR2 antikoerper, LOC718120 antikoerper

Hintergrund: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.,CR1,C3BR,C4BR,CD35,KN,Immunology & Inflammation,CD markers,Stem Cells,Hematopoietic Progenitors,CR1

Molekulargewicht: 223 kDa

Gen-ID: 1378

UniProt: P17927

Pathways: Komplementsystem, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Endopeptidase Activity