CDKN2A Antikörper

Produktnummer ABIN6139280

Produktdetails anti-CDKN2A Antikörper

Target: CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CDKN2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human CDKN2A/p16INK4a

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CDKN2A

Target: CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

Andere Bezeichnung: CDKN2A (CDKN2A Produkte)

Synonyme: Arf antikoerper, p16 antikoerper, MTS1 antikoerper, INK4A antikoerper, p19ARF antikoerper, p16Cdkn2a antikoerper, ARF antikoerper, CDK4I antikoerper, CDKN2 antikoerper, CMM2 antikoerper, INK4 antikoerper, MLM antikoerper, MTS-1 antikoerper, P14 antikoerper, P14ARF antikoerper, P16 antikoerper, P16-INK4A antikoerper, P16INK4 antikoerper, P16INK4A antikoerper, P19 antikoerper, P19ARF antikoerper, TP16 antikoerper, ARF-INK4a antikoerper, INK4a-ARF antikoerper, Ink4a/Arf antikoerper, Pctr1 antikoerper, p16(INK4a) antikoerper, p16INK4a antikoerper, p19 antikoerper, cyclin-dependent kinase inhibitor 2A antikoerper, cyclin dependent kinase inhibitor 2A antikoerper, Cdkn2a antikoerper, LOC100731972 antikoerper, LOC100340625 antikoerper, CDKN2A antikoerper

Hintergrund: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012],ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16,Apoptosis,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Cell Cycle_Cell cycle inhibitors,G1/S Checkpoint,G2/M DNA Damage Checkpoint,Kinase,Signal Transduction,CDKN2A

Molekulargewicht: 17 kDa

Gen-ID: 1029

UniProt: P42771

Pathways: Mitotic G1-G1/S Phases, Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Autophagie, Positive Regulation of Response to DNA Damage Stimulus