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DAAM2 Antikörper (AA 1-86)

DAAM2 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6139383
  • Target Alle DAAM2 Produkte
    DAAM2 (Dishevelled Associated Activator of Morphogenesis 2 (DAAM2))
    Bindungsspezifität
    • 15
    • 9
    • 8
    • 5
    • 3
    • 1
    • 1
    AA 1-86
    Reaktivität
    • 42
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 41
    • 1
    Kaninchen
    Klonalität
    • 41
    • 1
    Polyklonal
    Konjugat
    • 14
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DAAM2 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 20
    • 16
    • 13
    • 13
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Sequenz
    MAPRKRSHHG LGFLCCFGGS DIPEINLRDN HPLQFMEFSS PIPNAEELNI RFAELVDELD LTDKNREAMF ALPPEKKWQI YCSKKK
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-86 of human DAAM2 (NP_056160.2).
    Isotyp
    IgG
  • Applikationshinweise
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Kommentare

    HIGH QUALITY

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    DAAM2 (Dishevelled Associated Activator of Morphogenesis 2 (DAAM2))
    Andere Bezeichnung
    DAAM2 (DAAM2 Produkte)
    Synonyme
    dJ90A20A.1 antikoerper, 2310016D11Rik antikoerper, AI843643 antikoerper, AW557870 antikoerper, DAAM2 antikoerper, dishevelled associated activator of morphogenesis 2 antikoerper, DAAM2 antikoerper, Daam2 antikoerper, daam2 antikoerper
    Hintergrund
    Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1. Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly.,DAAM2,dJ90A20A.1,Stem Cells,DAAM2
    Molekulargewicht
    123 kDa
    Gen-ID
    23500
    UniProt
    Q86T65
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