DAAM2 Antikörper (AA 1-86)
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- Target Alle DAAM2 Produkte
- DAAM2 (Dishevelled Associated Activator of Morphogenesis 2 (DAAM2))
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Bindungsspezifität
- AA 1-86
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DAAM2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF)
- Sequenz
- MAPRKRSHHG LGFLCCFGGS DIPEINLRDN HPLQFMEFSS PIPNAEELNI RFAELVDELD LTDKNREAMF ALPPEKKWQI YCSKKK
- Kreuzreaktivität
- Human, Maus, Ratte
- Produktmerkmale
- Polyclonal Antibodies
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-86 of human DAAM2 (NP_056160.2).
- Isotyp
- IgG
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- Applikationshinweise
- WB,1:500 - 1:2000,IF,1:50 - 1:200
- Kommentare
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HIGH QUALITY
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- DAAM2 (Dishevelled Associated Activator of Morphogenesis 2 (DAAM2))
- Andere Bezeichnung
- DAAM2 (DAAM2 Produkte)
- Synonyme
- dJ90A20A.1 antikoerper, 2310016D11Rik antikoerper, AI843643 antikoerper, AW557870 antikoerper, DAAM2 antikoerper, dishevelled associated activator of morphogenesis 2 antikoerper, DAAM2 antikoerper, Daam2 antikoerper, daam2 antikoerper
- Hintergrund
- Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1. Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly.,DAAM2,dJ90A20A.1,Stem Cells,DAAM2
- Molekulargewicht
- 123 kDa
- Gen-ID
- 23500
- UniProt
- Q86T65
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