DNMT1 Antikörper (AA 1-270)
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- Target Alle DNMT1 Antikörper anzeigen
- DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
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Bindungsspezifität
- AA 1-270
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DNMT1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
- Sequenz
- MPARTAPARV PTLAVPAISL PDDVRRRLKD LERDSLTEKE CVKEKLNLLH EFLQTEIKNQ LCDLETKLRK EELSEEGYLA KVKSLLNKDL SLENGAHAYN REVNGRLENG NQARSEARRV GMADANSPPK PLSKPRTPRR SKSDGEAKPE PSPSPRITRK STRQTTITSH FAKGPAKRKP QEESERAKSD ESIKEEDKDQ DEKRRRVTSR ERVARPLPAE EPERAKSGTR TEKEEERDEK EEKRLRSQTK EPTPKQKLKE EPDREARAGV
- Kreuzreaktivität
- Human
- Produktmerkmale
- Polyclonal Antibodies
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DNMT1 (NP_001370.1).
- Isotyp
- IgG
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- Applikationshinweise
- WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:100
- Kommentare
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HIGH QUALITY
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1." in: Biomaterials, Vol. 155, pp. 203-216, (2018) (PubMed).
: "DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells." in: FEBS letters, Vol. 591, Issue 13, pp. 1929-1939, (2017) (PubMed).
: "Anticancer drugs induce hypomethylation of the acetylcholinesterase promoter via a phosphorylated-p38-DNMT1-AChE pathway in apoptotic hepatocellular carcinoma cells." in: The international journal of biochemistry & cell biology, Vol. 68, pp. 21-32, (2016) (PubMed).
: "
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Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1." in: Biomaterials, Vol. 155, pp. 203-216, (2018) (PubMed).
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- Target
- DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
- Andere Bezeichnung
- DNMT1 (DNMT1 Produkte)
- Synonyme
- cb1075 antikoerper, cb983 antikoerper, dmnt1 antikoerper, fb05h01 antikoerper, mta antikoerper, wu:fb05h01 antikoerper, ADCADN antikoerper, AIM antikoerper, CXXC9 antikoerper, DNMT antikoerper, HSN1E antikoerper, MCMT antikoerper, DDM2 antikoerper, DECREASED DNA METHYLATION 2 antikoerper, DMT01 antikoerper, DMT1 antikoerper, DNA METHYLTRANSFERASE antikoerper, DNA METHYLTRANSFERASE 01 antikoerper, DNA METHYLTRANSFERASE 1 antikoerper, MET2 antikoerper, METHYLTRANSFERASE 2 antikoerper, METHYLTRANSFERASE I antikoerper, METI antikoerper, methyltransferase 1 antikoerper, Cxxc9 antikoerper, Dnmt antikoerper, Dnmt1o antikoerper, MTase antikoerper, Met-1 antikoerper, Met1 antikoerper, MommeD2 antikoerper, m.MmuI antikoerper, DNA methyltransferase 1 antikoerper, DNA (cytosine-5-)-methyltransferase 1 antikoerper, methyltransferase 1 antikoerper, DNA methyltransferase (cytosine-5) 1 antikoerper, DNMT1 antikoerper, dnmt1 antikoerper, Dnmt1 antikoerper, MET1 antikoerper
- Hintergrund
- This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.,ADCADN,AIM,CXXC9,DNMT,HSN1E,MCMT,m.HsaI,DNMT1,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,DNA methylation,DNMT1
- Molekulargewicht
- 144 kDa/183 kDa/184 kDa
- Gen-ID
- 1786
- UniProt
- P26358
- Pathways
- SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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