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EXOSC4 Antikörper (AA 1-245)

EXOSC4 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6140378
  • Target Alle EXOSC4 Antikörper anzeigen
    EXOSC4 (Exosome Component 4 (EXOSC4))
    Bindungsspezifität
    • 15
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-245
    Reaktivität
    • 28
    • 22
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 40
    • 3
    Kaninchen
    Klonalität
    • 41
    • 2
    Polyklonal
    Konjugat
    • 19
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EXOSC4 Antikörper ist unkonjugiert
    Applikation
    • 26
    • 22
    • 13
    • 13
    • 7
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    MAGLELLSDQ GYRVDGRRAG ELRKIQARMG VFAQADGSAY IEQGNTKALA VVYGPHEIRG SRARALPDRA LVNCQYSSAT FSTGERKRRP HGDRKSCEMG LQLRQTFEAA ILTQLHPRSQ IDIYVQVLQA DGGTYAACVN AATLAVLDAG IPMRDFVCAC SAGFVDGTAL ADLSHVEEAA GGPQLALALL PASGQIALLE MDARLHEDHL ERVLEAAAQA ARDVHTLLDR VVRQHVREAS ILLGD
    Kreuzreaktivität
    Human, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human EXOSC4 (NP_061910.1).
    Isotyp
    IgG
    Top Product
    Discover our top product EXOSC4 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000,IHC,1:100 - 1:200
    Kommentare

    HIGH QUALITY

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    EXOSC4 (Exosome Component 4 (EXOSC4))
    Andere Bezeichnung
    EXOSC4 (EXOSC4 Produkte)
    Synonyme
    EXOSC4 antikoerper, zgc:73175 antikoerper, RRP41 antikoerper, RRP41A antikoerper, Rrp41p antikoerper, SKI6 antikoerper, Ski6p antikoerper, hRrp41p antikoerper, p12A antikoerper, 1110039I09Rik antikoerper, 1500001N04Rik antikoerper, Rrp41 antikoerper, exosome component 4 antikoerper, exosome component 4 S homeolog antikoerper, exosc4 antikoerper, EXOSC4 antikoerper, CC1G_03561 antikoerper, exosc4.S antikoerper, Exosc4 antikoerper
    Hintergrund
    Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR and/or Ig variable region somatic hypermutation (SHM by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9 is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.,EXOSC4,RRP41,RRP41A,Rrp41p,SKI6,Ski6p,hRrp41p,p12A,Epigenetics & Nuclear Signaling,EXOSC4
    Molekulargewicht
    26 kDa
    Gen-ID
    54512
    UniProt
    Q9NPD3
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