GALE Antikörper (AA 129-348)

Produktnummer ABIN6140933

Produktdetails anti-GALE Antikörper

Target: GALE (UDP-Galactose-4-Epimerase (GALE))

Bindungsspezifität: AA 129-348

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GALE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: FSSSATVYGN PQYLPLDEAH PTGGCTNPYG KSKFFIEEMI RDLCQADKTW NAVLLRYFNP TGAHASGCIG EDPQGIPNNL MPYVSQVAIG RREALNVFGN DYDTEDGTGV RDYIHVVDLA KGHIAALRKL KEQCGCRIYN LGTGTGYSVL QMVQAMEKAS GKKIPYKVVA RREGDVAACY ANPSLAQEEL GWTAALGLDR MCEDLWRWQK QNPSGFGTQA

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 129-348 of human GALE (NP_001121093.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu GALE

Target: GALE (UDP-Galactose-4-Epimerase (GALE))

Andere Bezeichnung: GALE (GALE Produkte)

Hintergrund: This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.,GALE,SDR1E1,Cancer,Signal Transduction,Endocrine & Metabolism,Carbohydrate metabolism,GALE

Molekulargewicht: 30 kDa/38 kDa

Gen-ID: 2582

UniProt: Q14376

Pathways: Response to Water Deprivation, Cellular Glucan Metabolic Process