Geminin Antikörper (AA 1-209)

Produktnummer ABIN6141186

Produktdetails anti-Geminin Antikörper

Target: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Bindungsspezifität: AA 1-209

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Geminin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: MNPSMKQKQE EIKENIKNSS VPRRTLKMIQ PSASGSLVGR ENELSAGLSK RKHRNDHLTS TTSSPGVIVP ESSENKNLGG VTQESFDLMI KENPSSQYWK EVAEKRRKAL YEALKENEKL HKEIEQKDNE IARLKKENKE LAEVAEHVQY MAELIERLNG EPLDNFESLD NQEFDSEEET VEDSLVEDSE IGTCAEGTVS SSTDAKPCI

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human GMNN (NP_056979.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Geminin

Target: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Andere Bezeichnung: GMNN (GMNN Produkte)

Synonyme: CG3183 antikoerper, Dm Geminin antikoerper, Dm geminin antikoerper, Dmel\\CG3183 antikoerper, Gem antikoerper, Geminin antikoerper, anon-WO0257455.1 antikoerper, gem antikoerper, l(2)k14019 antikoerper, v(2)k09107 antikoerper, sb:cb254 antikoerper, zgc:66217 antikoerper, GB16871 antikoerper, GMNN antikoerper, geminin antikoerper, dyak_GLEANR_833 antikoerper, DyakGE24654 antikoerper, GE24654 antikoerper, LOC100049517 antikoerper, AW546347 antikoerper, geminin, DNA replication inhibitor antikoerper, CG3183 gene product from transcript CG3183-RA antikoerper, geminin antikoerper, GE24654 gene product from transcript GE24654-RA antikoerper, GMNN antikoerper, geminin antikoerper, gmnn antikoerper, LOC410093 antikoerper, Dyak\geminin antikoerper, Gmnn antikoerper

Hintergrund: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.,GMNN,Gem,MGORS6,geminin,Epigenetics & Nuclear Signaling,Cancer,Cell Biology & Developmental Biology,Cell Cycle,GMNN

Molekulargewicht: 23 kDa

Gen-ID: 51053

UniProt: O75496

Pathways: EGFR Signaling Pathway, DNA Replication