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GNA12 Antikörper (AA 1-200)

GNA12 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6141192
  • Target Alle GNA12 Antikörper anzeigen
    GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
    Bindungsspezifität
    • 15
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-200
    Reaktivität
    • 44
    • 15
    • 15
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Human
    Wirt
    • 44
    • 1
    Kaninchen
    Klonalität
    • 45
    Polyklonal
    Konjugat
    • 16
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GNA12 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 17
    • 13
    • 13
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    MSGVVRTLSR CLLPAEAGGA RERRAGSGAR DAEREARRRS RDIDALLARE RRAVRRLVKI LLLGAGESGK STFLKQMRII HGREFDQKAL LEFRDTIFDN ILKGSRVLVD ARDKLGIPWQ YSENEKHGMF LMAFENKAGL PVEPATFQLY VPALSALWRD SGIREAFSRR SEFQLGESVK YFLDNLDRIG QLNYFPSKQD
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GNA12 (NP_031379.2).
    Isotyp
    IgG
    Top Product
    Discover our top product GNA12 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000,IHC,1:50 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
    Andere Bezeichnung
    GNA12 (GNA12 Produkte)
    Synonyme
    NNX3 antikoerper, RMP antikoerper, gep antikoerper, gna12 antikoerper, gna12l antikoerper, AI414047 antikoerper, AI504261 antikoerper, Galpha12 antikoerper, G protein subunit alpha 12 antikoerper, guanine nucleotide binding protein (G protein) alpha 12a antikoerper, guanine nucleotide binding protein, alpha 12 antikoerper, GNA12 antikoerper, Gna12 antikoerper, gna12a antikoerper
    Hintergrund
    Guanine nucleotide-binding proteins (G proteins are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG. GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1 (By similarity. GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.,GNA12,NNX3,RMP,gep,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,G protein signaling,mTOR Signaling Pathway,MAPK-JNK Signaling Pathway,GNA12
    Molekulargewicht
    34 kDa/37 kDa/44 kDa
    Gen-ID
    2768
    UniProt
    Q03113
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