HYOU1 Antikörper (AA 1-140)

Produktnummer ABIN6142107

Produktdetails anti-HYOU1 Antikörper

Target: HYOU1 (Hypoxia Up Regulated 1 (HYOU1))

Bindungsspezifität: AA 1-140

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HYOU1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: MADKVRRQRP RRRVCWALVA VLLADLLALS DTLAVMSVDL GSESMKVAIV KPGVPMEIVL NKESRRKTPV IVTLKENERF FGDSAASMAI KNPKATLRYF QHLLGKQADN PHVALYQARF PEHELTFDPQ RQTVHFQISS

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ORP150/GRP170/HSP12A (NP_001124463.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HYOU1

Target: HYOU1 (Hypoxia Up Regulated 1 (HYOU1))

Andere Bezeichnung: HYOU1 (HYOU1 Produkte)

Synonyme: GRP-170 antikoerper, Grp170 antikoerper, HSP12A antikoerper, ORP-150 antikoerper, ORP150 antikoerper, AI415631 antikoerper, CBP-140 antikoerper, Cab140 antikoerper, Orp150 antikoerper, id:ibd5056 antikoerper, wu:fd14c05 antikoerper, zgc:56019 antikoerper, HYOU1 antikoerper, orp150 antikoerper, GRP170 antikoerper, hypoxia up-regulated 1 antikoerper, hypoxia up-regulated protein 1 antikoerper, hypoxia up-regulated 1 S homeolog antikoerper, HYOU1 antikoerper, Hyou1 antikoerper, hyou1 antikoerper, LOC100380749 antikoerper, hyou1.S antikoerper

Hintergrund: The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants.,HYOU1,GRP-170,Grp170,HSP12A,ORP-150,ORP150,Epigenetics & Nuclear Signaling,Cancer,Invasion and Metastasis,Signal Transduction,Endocrine & Metabolism,Neuroscience,Neurodegenerative Diseases,Cardiovascular,Hypoxia,Hypoxia-related proteins,HYOU1

Molekulargewicht: 62 kDa/111 kDa

Gen-ID: 10525

UniProt: Q9Y4L1

Pathways: ER-Nucleus Signaling, SARS-CoV-2 Protein Interaktom