Laminin beta 1 Antikörper (AA 1467-1786)

Produktnummer ABIN6143068

Produktdetails anti-Laminin beta 1 Antikörper

Target: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Bindungsspezifität: AA 1467-1786

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Laminin beta 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: EAKLRADEAK QSAEDILLKT NATKEKMDKS NEELRNLIKQ IRNFLTQDSA DLDSIEAVAN EVLKMEMPST PQQLQNLTED IRERVESLSQ VEVILQHSAA DIARAEMLLE EAKRASKSAT DVKVTADMVK EALEEAEKAQ VAAEKAIKQA DEDIQGTQNL LTSIESETAA SEETLFNASQ RISELERNVE ELKRKAAQNS GEAEYIEKVV YTVKQSAEDV KKTLDGELDE KYKKVENLIA KKTEESADAR RKAEMLQNEA KTLLAQANSK LQLLKDLERK YEDNQRYLED KAQELARLEG EVRSLLKDIS QKVAVYSTCL

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1467-1786 of human Laminin beta 1 (NP_002282.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:4000,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Laminin beta 1

Target: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Andere Bezeichnung: LAMB1 (LAMB1 Produkte)

Synonyme: CLM antikoerper, LIS5 antikoerper, fc20b05 antikoerper, gup antikoerper, lamb1 antikoerper, sb:cb95 antikoerper, wu:fc20b05 antikoerper, Lamb1-1 antikoerper, LAMB1 antikoerper, C77966 antikoerper, C80098 antikoerper, C81607 antikoerper, D130003D08Rik antikoerper, Lamb-1 antikoerper, laminin subunit beta 1 antikoerper, laminin, beta 1a antikoerper, laminin B1 antikoerper, LAMB1 antikoerper, lamb1a antikoerper, Lamb1 antikoerper, lamb1 antikoerper

Hintergrund: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.,LAMB1,CLM,LIS5,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Cardiovascular,Angiogenesis,LAMB1

Molekulargewicht: 198 kDa

Gen-ID: 3912

UniProt: P07942