LAMB2 Antikörper (AA 1579-1798)

Produktnummer ABIN6143070

Produktdetails anti-LAMB2 Antikörper

Target: LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))

Bindungsspezifität: AA 1579-1798

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LAMB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: DVRRAEQLLQ DARRARSWAE DEKQKAETVQ AALEEAQRAQ GIAQGAIRGA VADTRDTEQT LYQVQERMAG AERALSSAGE RARQLDALLE ALKLKRAGNS LAASTAEETA GSAQGRAQEA EQLLRGPLGD QYQTVKALAE RKAQGVLAAQ ARAEQLRDEA RDLLQAAQDK LQRLQELEGT YEENERALES KAAQLDGLEA RMRSVLQAIN LQVQIYNTCQ

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1579-1798 of human LAMB2 (NP_002283.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu LAMB2

Target: LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))

Andere Bezeichnung: LAMB2 (LAMB2 Produkte)

Synonyme: LAMS antikoerper, NPHS5 antikoerper, AW211941 antikoerper, Lamb-2 antikoerper, Lams antikoerper, SLAM antikoerper, lamb1 antikoerper, lams antikoerper, LAMC1 antikoerper, laminin antikoerper, laminin subunit beta 2 antikoerper, laminin, beta 2 antikoerper, laminin subunit beta 2 L homeolog antikoerper, laminin, beta 2 (laminin S) antikoerper, LAMB2 antikoerper, Lamb2 antikoerper, lamb2.L antikoerper

Hintergrund: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma . Some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form.,LAMB2,LAMS,NPHS5,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Intermediate Filaments,Extracellular Matrix,Neuroscience,Cardiovascular,Angiogenesis,LAMB2

Molekulargewicht: 195 kDa

Gen-ID: 3913

UniProt: P55268

Pathways: Skeletal Muscle Fiber Development