LAMC2 Antikörper (AA 862-1111)

Produktnummer ABIN6143076

Produktdetails anti-LAMC2 Antikörper

Target: LAMC2 (Laminin, gamma 2 (LAMC2))

Bindungsspezifität: AA 862-1111

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LAMC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: SDQSFQVEEA KRIKQKADSL SSLVTRHMDE FKRTQKNLGN WKEEAQQLLQ NGKSGREKSD QLLSRANLAK SRAQEALSMG NATFYEVESI LKNLREFDLQ VDNRKAEAEE AMKRLSYISQ KVSDASDKTQ QAERALGSAA ADAQRAKNGA GEALEISSEI EQEIGSLNLE ANVTADGALA MEKGLASLKS EMREVEGELE RKELEFDTNM DAVQMVITEA QKVDTRAKNA GVTIQDTLNT LDGLLHLMGM

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 862-1111 of human LAMC2 (NP_061486.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu LAMC2

Target: LAMC2 (Laminin, gamma 2 (LAMC2))

Andere Bezeichnung: LAMC2 (LAMC2 Produkte)

Synonyme: LAMC2 antikoerper, B2T antikoerper, BM600 antikoerper, CSF antikoerper, EBR2 antikoerper, EBR2A antikoerper, LAMB2T antikoerper, LAMNB2 antikoerper, AA589349 antikoerper, laminin subunit gamma 2 antikoerper, laminin, gamma 2 antikoerper, LAMC2 antikoerper, Lamc2 antikoerper

Hintergrund: This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain, however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.,LAMC2,B2T,BM600,CSF,EBR2,EBR2A,LAMB2T,LAMNB2,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Neuroscience,LAMC2

Molekulargewicht: 121 kDa/130 kDa

Gen-ID: 3918

UniProt: Q13753