MEPCE Antikörper (AA 470-689)

Produktnummer ABIN6143737

Produktdetails anti-MEPCE Antikörper

Target: MEPCE (Methylphosphate Capping Enzyme (MEPCE))

Bindungsspezifität: AA 470-689

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEPCE Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Sequenz: MVGLDIDSRL IHSARQNIRH YLSEELRLPP QTLEGDPGAE GEEGTTTVRK RSCFPASLTA SRGPIAAPQV PLDGADTSVF PNNVVFVTGN YVLDRDDLVE AQTPEYDVVL CLSLTKWVHL NWGDEGLKRM FRRIYRHLRP GGILVLEPQP WSSYGKRKTL TETIYKNYYR IQLKPEQFSS YLTSPDVGFS SYELVATPHN TSKGFQRPVY LFHKARSPSH

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 470-689 of human MEPCE (NP_062552.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MEPCE

Target: MEPCE (Methylphosphate Capping Enzyme (MEPCE))

Andere Bezeichnung: MEPCE (MEPCE Produkte)

Hintergrund: S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA, leading to stabilize it. Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC. In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex. MEPCE has a non-enzymatic function in the 7SK RNP complex, interaction with LARP7 within the 7SK RNP complex occluding its catalytic center.,MEPCE,BCDIN3,Epigenetics & Nuclear Signaling,RNA Binding,MEPCE

Molekulargewicht: 24 kDa/74 kDa

Gen-ID: 56257

UniProt: Q7L2J0

Pathways: Chromatin Binding, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion