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METTL14 Antikörper (AA 1-210)

METTL14 Reaktivität: Human WB, IP, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6143759
  • Target Alle METTL14 Antikörper anzeigen
    METTL14 (Methyltransferase Like 14 (METTL14))
    Bindungsspezifität
    • 15
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-210
    Reaktivität
    • 27
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 26
    • 1
    Kaninchen
    Klonalität
    • 27
    Polyklonal
    Konjugat
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser METTL14 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 13
    • 13
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Sequenz
    MDSRLQEIRE RQKLRRQLLA QQLGAESADS IGAVLNSKDE QREIAETRET CRASYDTSAP NAKRKYLDEG ETDEDKMEEY KDELEMQQDE ENLPYEEEIY KDSSTFLKGT QSLNPHNDYC QHFVDTGHRP QNFIRDVGLA DRFEEYPKLR ELIRLKDELI AKSNTPPMYL QADIEAFDIR ELTPKFDVIL LEPPLEEYYR ETGITANEKC
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human METTL14 (NP_066012.1).
    Isotyp
    IgG
  • Applikationshinweise
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Xiang, Yang, Liu, Wu, Chen, Yang: "N6-Methyladenosines Modulate A-to-I RNA Editing." in: Molecular cell, Vol. 69, Issue 1, pp. 126-135.e6, (2018) (PubMed).

    Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).

    Yoon, Ringeling, Vissers, Jacob, Pokrass, Jimenez-Cyrus, Su, Kim, Zhu, Zheng, Kim, Wang, Doré, Jin, Regot, Zhuang, Canzar, He, Ming, Song: "Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation." in: Cell, Vol. 171, Issue 4, pp. 877-889.e17, (2017) (PubMed).

  • Target
    METTL14 (Methyltransferase Like 14 (METTL14))
    Andere Bezeichnung
    METTL14 (METTL14 Produkte)
    Synonyme
    RGD1304822 antikoerper, G430022H21Rik antikoerper, mKIAA1627 antikoerper, zgc:77296 antikoerper, methyltransferase like 14 antikoerper, methyltransferase like 14 L homeolog antikoerper, Mettl14 antikoerper, mettl14.L antikoerper, METTL14 antikoerper, mettl14 antikoerper
    Hintergrund
    The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6 position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A, which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity. In embryonic stem cells (ESCs, m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity.,METTL14,hMETTL14,Cell Biology & Developmental Biology,METTL14
    Molekulargewicht
    52 kDa
    Gen-ID
    57721
    UniProt
    Q9HCE5
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