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METTL4 Antikörper (AA 1-190)

METTL4 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6143773
  • Target Alle METTL4 Antikörper anzeigen
    METTL4 (Methyltransferase Like 4 (METTL4))
    Bindungsspezifität
    • 10
    • 9
    • 7
    • 1
    • 1
    AA 1-190
    Reaktivität
    • 21
    • 12
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 20
    • 1
    Kaninchen
    Klonalität
    • 21
    Polyklonal
    Konjugat
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser METTL4 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 14
    • 14
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Sequenz
    MSVVHQLSAG WLLDHLSFIN KINYQLHQHH EPCCRKKEFT TSVHFESLQM DSVSSSGVCA AFIASDSSTK PENDDGGNYE MFTRKFVFRP ELFDVTKPYI TPAVHKECQQ SNEKEDLMNG VKKEISISII GKKRKRCVVF NQGELDAMEY HTKIRELILD GSLQLIQEGL KSGFLYPLFE KQDKGSKPIT
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human METTL4 (NP_073751.3).
    Isotyp
    IgG
  • Applikationshinweise
    WB,1:1000 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    METTL4 (Methyltransferase Like 4 (METTL4))
    Andere Bezeichnung
    METTL4 (METTL4 Produkte)
    Synonyme
    HsT661 antikoerper, 2410198H06Rik antikoerper, A730091E08Rik antikoerper, AV296509 antikoerper, RGD1306451 antikoerper, methyltransferase like 4 antikoerper, METTL4 antikoerper, Mettl4 antikoerper
    Hintergrund
    N(6-adenine-specific methyltransferase that can methylate both RNAs and DNA. Acts as a N(6-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m on internal positions of U2 small nuclear RNA (snRNA: methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation. Internal m6A(m methylation of snRNAs regulates RNA splicing. Also able to act as a N(6-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6-methyladenosine. The existence of N(6-methyladenosine (m6A on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6-adenine-specific DNA methyltransferase activity of METTL4 in vivo. Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA copy number by mediating mtDNA N(6-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending. N(6-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity.,METTL4,HsT661,Epigenetics & Nuclear Signaling,METTL4
    Molekulargewicht
    54 kDa
    Gen-ID
    64863
    UniProt
    Q8N3J2
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