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MLKL Antikörper

MLKL Reaktivität: Maus WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6143883
  • Target Alle MLKL Antikörper anzeigen
    MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
    Reaktivität
    • 56
    • 39
    • 17
    • 1
    • 1
    Maus
    Wirt
    • 67
    • 7
    Kaninchen
    Klonalität
    • 60
    • 14
    Polyklonal
    Konjugat
    • 32
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    Dieser MLKL Antikörper ist unkonjugiert
    Applikation
    • 32
    • 29
    • 13
    • 10
    • 6
    • 5
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität
    Human, Maus
    Produktmerkmale
    Polyclonal Antibodies
    Immunogen
    Recombinant protein of mouse MLKL
    Isotyp
    IgG
    Top Product
    Discover our top product MLKL Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    Kommentare

    HIGH QUALITY

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Qin, Yang, Huang, Du, Mai, Xiao, Lü: "Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia." in: Pharmacological research, Vol. 133, pp. 218-235, (2018) (PubMed).

    Zhang, Lyu, Liu, Lv, Chang, Rubinsky: "Molecular and histological study on the effects of non-thermal irreversible electroporation on the liver." in: Biochemical and biophysical research communications, Vol. 500, Issue 3, pp. 665-670, (2018) (PubMed).

    Huang, Zheng, Wang, Chen, He, Zhang, Xu, Zhao, Shi, Wang, Zhu, Han: "The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process." in: Molecular and cellular biology, Vol. 37, Issue 5, (2017) (PubMed).

  • Target
    MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
    Andere Bezeichnung
    MLKL (MLKL Produkte)
    Synonyme
    MLKL antikoerper, 9130019I15Rik antikoerper, mixed lineage kinase domain like pseudokinase antikoerper, mixed lineage kinase domain-like antikoerper, MLKL antikoerper, mlkl antikoerper, Mlkl antikoerper
    Hintergrund
    This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.,MLKL,hMLKL,Signal Transduction,Kinase,MLKL
    Molekulargewicht
    53 kDa/54 kDa
    Gen-ID
    74568
    UniProt
    Q9D2Y4
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