FASL
(Fas Ligand (TNF Superfamily, Member 6) (FASL))
Reaktivität
Maus, Ratte
Wirt
Hamster
Klonalität
Monoklonal
Konjugat
Dieser FASL Antikörper ist konjugiert mit FITC
Applikation
Flow Cytometry (FACS)
Spezifität
Recognizes both Mouse and Rat CD178. Clone MFL4 is reported to block CD178/CD95 induced apoptosis. We recommend the use of AM20860LE-N for functional studies.
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
0.1 mg/mL
Buffer
PBS containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light.
Target
FASL
(Fas Ligand (TNF Superfamily, Member 6) (FASL))
CD178, otherwise known as Fas Ligand/ CD95L, a 40 kDa type II transmembrane glycoprotein and member of the TNF/NGF superfamily, expressed by activated T cells and NK cells, which can be induced on a variety of cells by radiation, heat shock, chemotherapeutic agents and viral infection. CD178 acts as a key effector of cytotoxicity and in the regulation of immune responses. The binding of CD178 to its receptor CD95 (Fas), induces Fas-mediated apoptosis of target cells, and may be involved in the induction of peripheral tolerance and neutrophil chemotaxis. The binding of decoy receptor 3 (DcR3) to CD178 has been shown to inhibit CD178-mediated apoptosis.Synonyms: APT1LG1, APTL, Apoptosis antigen ligand, CD95L protein, FASL, FASLG, Fas antigen ligand, TNFSF6, Tumor necrosis factor ligand superfamily member 6