NOXA Antikörper (AA 1-54)

Produktnummer ABIN6145810

Produktdetails anti-NOXA Antikörper

Target: NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))

Bindungsspezifität: AA 1-54

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOXA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: MPGKKARKNA QPSPARAPAE LEVECATQLR RFGDKLNFRQ KLLNLISKLF CSGT

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-54 of human PMAIP1 (NP_066950.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NOXA

Target: NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))

Andere Bezeichnung: PMAIP1 (PMAIP1 Produkte)

Synonyme: TN3 antikoerper, PMAIP1 antikoerper, zgc:162379 antikoerper, APR antikoerper, NOXA antikoerper, Noxa antikoerper, phorbol-12-myristate-13-acetate-induced protein 1 antikoerper, PMAIP1 antikoerper, pmaip1 antikoerper, Pmaip1 antikoerper

Hintergrund: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.,PMAIP1,APR,NOXA,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Apoptosis,Bcl 2 family,Mitochondrial Control of Apoptosis,Endocrine & Metabolism,PMAIP1

Molekulargewicht: 6 kDa/14 kDa

Gen-ID: 5366

UniProt: Q13794

Pathways: p53 Signalweg, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus