PMS2 Antikörper (AA 390-670)

Produktnummer ABIN6145829

Produktdetails anti-PMS2 Antikörper

Target: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Bindungsspezifität: AA 390-670

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PMS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ADLEKPMVEK QDQSPSLRTG EEKKDVSISR LREAFSLRHT TENKPHSPKT PEPRRSPLGQ KRGMLSSSTS GAISDKGVLR PQKEAVSSSH GPSDPTDRAE VEKDSGHGST SVDSEGFSIP DTGSHCSSEY AASSPGDRGS QEHVDSQEKA PKTDDSFSDV DCHSNQEDTG CKFRVLPQPT NLATPNTKRF KKEEILSSSD ICQKLVNTQD MSASQVDVAV KINKKVVPLD FSMSSLAKRI KQLHHEAQQS EGEQNYRKFR AKICPGENQA AEDELRKEIS K

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 390-670 of human PMS2 (NP_000526.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PMS2

Target: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Andere Bezeichnung: PMS2 (PMS2 Produkte)

Hintergrund: The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC, also known as Lynch syndrome) and Turcot syndrome.,PMS2,HNPCC4,MLH4,PMS2CL,PMSL2,PMS2

Molekulargewicht: 20 kDa/51 kDa/62 kDa/95 kDa

Gen-ID: 5395

UniProt: P54278

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response