RFFL Antikörper (AA 1-190)

Produktnummer ABIN6146886

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RFFL in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für RFFL Antikörper (AA 1-190) (ABIN6146886)

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFFL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RFFL Antikörper

Bindungsspezifität: AA 1-190

Sequenz: MWATCCNWFC LDGQPEEVPP PQGARMQAYS NPGYSSFPSP TGLEPSCKSC GAHFANTARK QTCLDCKKNF CMTCSSQVGN GPRLCLLCQR FRATAFQREE LMKMKVKDLR DYLSLHDIST EMCREKEELV LLVLGQQPVI SQEDRTRAST LSPDFPEQQA FLTQPHSSMV PPTSPNLPSS SAQATSVPPA

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RFFL (NP_001017368.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu RFFL

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Andere Bezeichnung: RFFL

Hintergrund: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.,RFFL,CARP-2,CARP2,FRING,RIFIFYLIN,RNF189,RNF34L,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Caspases,Ubiquitin,RFFL

Molekulargewicht: 36 kDa/39 kDa/40 kDa

Gen-ID: 117584

UniProt: Q8WZ73