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RIPK1 Antikörper (AA 170-440)

RIPK1 Reaktivität: Human WB, IHC, IP, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6146959
  • Target Alle RIPK1 Antikörper anzeigen
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Bindungsspezifität
    • 16
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 170-440
    Reaktivität
    • 84
    • 40
    • 28
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 80
    • 10
    Kaninchen
    Klonalität
    • 72
    • 18
    Polyklonal
    Konjugat
    • 34
    • 9
    • 8
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RIPK1 Antikörper ist unkonjugiert
    Applikation
    • 59
    • 33
    • 18
    • 15
    • 13
    • 13
    • 10
    • 10
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Sequenz
    NEEHNELREV DGTAKKNGGT LYYMAPEHLN DVNAKPTEKS DVYSFAVVLW AIFANKEPYE NAICEQQLIM CIKSGNRPDV DDITEYCPRE IISLMKLCWE ANPEARPTFP GIEEKFRPFY LSQLEESVEE DVKSLKKEYS NENAVVKRMQ SLQLDCVAVP SSRSNSATEQ PGSLHSSQGL GMGPVEESWF APSLEHPQEE NEPSLQSKLQ DEANYHLYGS RMDRQTKQQP RQNVAYNREE ERRRRVSHDP FAQQRPYENF QNTEGKGTAY S
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 170-440 of human RIPK1/RIP (NP_003795.2).
    Isotyp
    IgG
    Top Product
    Discover our top product RIPK1 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Andere Bezeichnung
    RIPK1 (RIPK1 Produkte)
    Synonyme
    RIP antikoerper, RIP1 antikoerper, D330015H01Rik antikoerper, Rinp antikoerper, Rip1 antikoerper, rip1 antikoerper, ripk1 antikoerper, xRIP1beta antikoerper, xrip1 antikoerper, receptor interacting serine/threonine kinase 1 antikoerper, receptor (TNFRSF)-interacting serine-threonine kinase 1 antikoerper, receptor interacting serine/threonine kinase 1 L homeolog antikoerper, RIPK1 antikoerper, Ripk1 antikoerper, ripk1.L antikoerper
    Hintergrund
    3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1 E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1 E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location.,RIP,RIP-1,RIP1,RIPK1,Cancer,Invasion and Metastasis,Signal Transduction,Kinase,Serine/threonine kinases,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Death receptors & ligands,Inhibition of Apoptosis,Death Receptor Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Toll-like Receptor Signaling Pathway,RIPK1
    Molekulargewicht
    70 kDa/75 kDa
    Gen-ID
    8737
    UniProt
    Q13546
    Pathways
    NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom, Ubiquitin Proteasome Pathway
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