RIPK3 Antikörper (AA 1-120)

Produktnummer ABIN6146964

Produktdetails anti-RIPK3 Antikörper

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Bindungsspezifität: AA 1-120

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIPK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequenz: MSCVKLWPSG APAPLVSIEE LENQELVGKG GFGTVFRAQH RKWGYDVAVK IVNSKAISRE VKAMASLDNE FVLRLEGVIE KVNWDQDPKP ALVTKFMENG SLSGLLQSQC PRPWPLLCRL

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human RIPK3 (NP_006862.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-RIPK3 Antikörper (ABIN6146964)

Qin, Yang, Huang, Du, Mai, Xiao, Lü: "Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia." in: Pharmacological research, Vol. 133, pp. 218-235, (2018) (PubMed).

Mengying, Yiyue, Tong, Yue, Limpanont, Ping, Okanurak, Yanqi, Dekumyoy, Hongli, Watthanakulpanich, Zhongdao, Zhi, Zhiyue: "Apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by Angiostrongylus cantonensis infection." in: Parasites & vectors, Vol. 10, Issue 1, pp. 611, (2018) (PubMed).

Huang, Zheng, Wang, Chen, He, Zhang, Xu, Zhao, Shi, Wang, Zhu, Han: "The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process." in: Molecular and cellular biology, Vol. 37, Issue 5, (2017) (PubMed).

Details zu RIPK3

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Andere Bezeichnung: RIPK3 (RIPK3 Produkte)

Synonyme: RIPK3 antikoerper, RIP3 antikoerper, 2610528K09Rik antikoerper, AW107945 antikoerper, Rip3 antikoerper, Hcyp2 antikoerper, receptor interacting serine/threonine kinase 3 antikoerper, receptor interacting serine/threonine kinase 3 S homeolog antikoerper, receptor-interacting serine-threonine kinase 3 antikoerper, RIPK3 antikoerper, ripk3.S antikoerper, Ripk3 antikoerper

Hintergrund: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.,RIPK3,RIP3,Signal Transduction,Kinase,Serine/threonine kinases,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Death Receptor Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Toll-like Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TLR Signaling,RIPK3

Molekulargewicht: 25 kDa/27 kDa/56 kDa

Gen-ID: 11035

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades