RPE65 Antikörper (AA 274-533)

Produktnummer ABIN6147090

Produktdetails anti-RPE65 Antikörper

Target: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Bindungsspezifität: AA 274-533

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RPE65 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: NYMDCFESNE TMGVWLHIAD KKRKKYLNNK YRTSPFNLFH HINTYEDNGF LIVDLCCWKG FEFVYNYLYL ANLRENWEEV KKNARKAPQP EVRRYVLPLN IDKADTGKNL VTLPNTTATA ILCSDETIWL EPEVLFSGPR QAFEFPQINY QKYCGKPYTY AYGLGLNHFV PDRLCKLNVK TKETWVWQEP DSYPSEPIFV SHPDALEEDD GVVLSVVVSP GAGQKPAYLL ILNAKDLSEV ARAEVEINIP VTFHGLFKKS

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 274-533 of human RPE65 (NP_000320.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu RPE65

Target: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Andere Bezeichnung: RPE65 (RPE65 Produkte)

Hintergrund: This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa.,RPE65,BCO3,LCA2,RP20,mRPE65,rd12,sRPE65,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,Cell Type Marker,RPE65

Molekulargewicht: 60 kDa

Gen-ID: 6121

UniProt: Q16518