SMURF2 Antikörper (AA 150-250)

Produktnummer ABIN6148161

Produktdetails anti-SMURF2 Antikörper

Target: SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))

Bindungsspezifität: AA 150-250

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMURF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DCSRLFDNDL PDGWEERRTA SGRIQYLNHI TRTTQWERPT RPASEYSSPG RPLSCFVDEN TPISGTNGAT CGQSSDPRLA ERRVRSQRHR NYMSRTHLHT P

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 150-250 of human SMURF2 (NP_073576.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SMURF2

Target: SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))

Andere Bezeichnung: SMURF2 (SMURF2 Produkte)

Synonyme: SMURF2 antikoerper, 2810411E22Rik antikoerper, AI558114 antikoerper, AI649275 antikoerper, RGD1310067 antikoerper, wu:fb82a11 antikoerper, wu:fc41c02 antikoerper, SMAD specific E3 ubiquitin protein ligase 2 antikoerper, SMAD specific E3 ubiquitin protein ligase 2 S homeolog antikoerper, SMURF2 antikoerper, smurf2 antikoerper, Smurf2 antikoerper, smurf2.S antikoerper

Hintergrund: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation. SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation. Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation.,SMURF2,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,TGF-b-Smad Signaling Pathway,Endocrine & Metabolism,Mitochondrial metabolism,Immunology & Inflammation,Stem Cells,SMURF2

Molekulargewicht: 86 kDa

Gen-ID: 64750

UniProt: Q9HAU4