TAB2 Antikörper (AA 350-693)

Produktnummer ABIN6148797

Produktdetails anti-TAB2 Antikörper

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Bindungsspezifität: AA 350-693

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: STSSSVNSQT LNRNQPTVYI AASPPNTDEL MSRSQPKVYI SANAATGDEQ VMRNQPTLFI STNSGASAAS RNMSGQVSMG PAFIHHHPPK SRAIGNNSAT SPRVVVTQPN TKYTFKITVS PNKPPAVSPG VVSPTFELTN LLNHPDHYVE TENIQHLTDP TLAHVDRISE TRKLSMGSDD AAYTQALLVH QKARMERLQR ELEIQKKKLD KLKSEVNEME NNLTRRRLKR SNSISQIPSL EEMQQLRSCN RQLQIDIDCL TKEIDLFQAR GPHFNPSAIH NFYDNIGFVG PVPPKPKDQR SIIKTPKTQD TEDDEGAQWN CTACTFLNHP ALIRCEQCEM PRHF

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 350-693 of human TAB2 (NP_001278963.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TAB2

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Andere Bezeichnung: TAB2 (TAB2 Produkte)

Synonyme: CHTD2 antikoerper, MAP3K7IP2 antikoerper, 1110030N06Rik antikoerper, A530078N03Rik antikoerper, Map3k7ip2 antikoerper, mKIAA0733 antikoerper, map3k7ip2 antikoerper, zgc:77446 antikoerper, TGF-beta activated kinase 1/MAP3K7 binding protein 2 antikoerper, TAB2 antikoerper, Tab2 antikoerper, tab2 antikoerper

Hintergrund: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.,TAB2,CHTD2,MAP3K7IP2,TAB-2,Signal Transduction,Kinase,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Wnt/β-Catenin Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Toll-like Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TLR Signaling,TAB2

Molekulargewicht: 58 kDa/76 kDa

Gen-ID: 23118

UniProt: Q9NYJ8

Pathways: T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway