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TP53INP1 Antikörper (AA 1-100)

TP53INP1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6149422
  • Target Alle TP53INP1 Antikörper anzeigen
    TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))
    Bindungsspezifität
    • 8
    • 8
    • 7
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-100
    Reaktivität
    • 49
    • 23
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 51
    Kaninchen
    Klonalität
    • 42
    • 8
    Polyklonal
    Konjugat
    • 24
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser TP53INP1 Antikörper ist unkonjugiert
    Applikation
    • 32
    • 24
    • 21
    • 12
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    MFQRLNKMFV GEVSSSSNQE PEFNEKEDDE WILVDFIDTC TGFSAEEEEE EEDISEESPT EHPSVFSCLP ASLECLADTS DSCFLQFESC PMEESWFITP
    Kreuzreaktivität
    Maus
    Produktmerkmale
    Polyclonal Antibodies
    Immunogen
    A synthetic peptide corresponding to a sequence within amino acids 1-100 of human p53 DINP1 (NP_001129205.1).
    Isotyp
    IgG
    Top Product
    Discover our top product TP53INP1 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))
    Andere Bezeichnung
    TP53INP1 (TP53INP1 Produkte)
    Hintergrund
    Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.,TP53INP1,SIP,TP53DINP1,TP53INP1A,TP53INP1B,Teap,p53DINP1,Cancer,Tumor suppressors,p53 pathway,Cell Biology & Developmental Biology,Apoptosis,Autophagy,TP53INP1
    Molekulargewicht
    18 kDa/27 kDa
    Gen-ID
    94241
    UniProt
    Q96A56
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