ULK1 Antikörper (AA 400-499)

Produktnummer ABIN6149921

Produktdetails anti-ULK1 Antikörper

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Bindungsspezifität: AA 400-499

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ULK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: RTPSPSPPCS SSPSPSGRAG PFSSSRCGAS VPIPVPTQVQ NYQRIERNLQ SPTQFQTPRS SAIRRSGSTS PLGFARASPS PPAHAEHGGV LARKMSLGGG

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 400-499 of human ULK1 (NP_003556.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:1000,IF,1:10 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-ULK1 Antikörper (ABIN6149921)

Xu, Zhang, Liu, Wu, Qin, Huang: "Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells." in: Oncology letters, Vol. 15, Issue 6, pp. 9719-9724, (2018) (PubMed).

Details zu ULK1

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Andere Bezeichnung: ULk1 (ULK1 Produkte)

Hintergrund: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1 via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy. Phosphorylates FLCN, promoting autophagy. Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation.,ULK1,ATG1,ATG1A,UNC51,Unc51.1,hATG1,ULk1,Signal Transduction,Kinase,Serine/threonine kinases,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Endocrine & Metabolism,Mitochondrial metabolism,Mitophagy fission and fusion,Neuroscience,Cardiovascular,Heart,Regulator of mTOR complex function,Regulators,ULk1

Molekulargewicht: 112 kDa

Gen-ID: 8408

UniProt: O75385

Pathways: Regulation of Cell Size, Autophagie